Project leaders

Professor Michael Sternberg (Imperial College London)

Research focus has been the development of algorithms to model the inter-relationships between protein sequence, structure and function. In blind testing at the last international meeting involving the prediction of protein structure (CASP4), the programs 3D-JIGSAW and 3D-PSSM performed amongst the best in the world. At CASP2 and CASP3, 3D-JIGSAW was evaluated as producing some of the best comparative models.

Professor David Jones (University College London)

Major research interests are in protein structure prediction, protein evolution, transmembrane protein modelling, genome analysis, and protein structure comparison and classification. He and his group have participated in all 4 CASP experiments where they have been ranked at or near the top in the fold recognition (CASP1 and CASP3), ab initio prediction (CASP2 and CASP4) and secondary structure prediction categories (CASP3 and CASP4).

Professor Janet Thornton (European Bioinformatics Institute)

Recent research has focused on understanding the relationship between protein structure and biological function, developing methods to use this to annotate protein sequences.

Biological researchers

Professor Christine Orengo (University College, London)

Recent research has focused on developing tools to improve structure classification and protein family analysis.

Dr Ewan Birney (European Bioinformatics Institute)

Research has been focused on providing the interpretation of DNA sequence for practical use by molecular biologists and research bioinformaticians. In particular, he is one of the co-directors of the Ensembl project, which provides consistent annotation across metazoan genomes, in particular the human genome.

Computational researchers

Professor John Darlington (Imperial College London)

Research focus has been on the development and application of parallel computers and software techniques for their effective application.

Dr Soren Sorensen (University College, London)

Research background is in the fields of large scale modelling and modelling environments. Current interests relate to load balancing, load planning and scheduling issues in large scale collaborating clusters.

Post-docs

Liam McGuffin (University College, London)

Currently working in David Jones's group at UCL, and has worked on the PSIPRED server and GenTHREADER amongst other projects.

Keiran Fleming (Imperial College London)

In Mike Sternberg's group at Imperial College, with a background in Structural Biology. Currently developing the 3D-Genomics database.

Stefano Street (University College, London)

Working in Soren Sorensen's group at UCL. Has experience with the GRID infrastructure.

Andreas Kahari (European Bioinformatics Institute)

In Ewan Birney’s group at the EBI. Has a varied background in numerical analysis, high performance parallel computing, software development for large scale breeding value computations, and more recently bioinformatics software development at the EBI.

Shikta Das (Imperial College London)

Holds an MSc in Bioinformatics from Birkbeck College.Since joining the London e-Science Centre at Imperial College in 2004, she has been working on deveoping the use of ICENI for the e-Protein Project with John Darlington and Andrew S. McGough.

Tim Massingham (European Bioinformatics Institute)

In Janet Thornton's group at the EBI. Currently working on the Catalytic Site Atlas (CSA) related databases